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Year : 2015  |  Volume : 2  |  Issue : 1  |  Page : 2

Intravitreal bevacizumab for choroidal metastases secondary to adenocarcinoma of the lung

1 Department of Ophthalmology, Northwestern University Feinberg School of Medicine; Department of Surgery, Division of Ophthalmology and Visual Sciences, The University of Chicago, Chicago, IL, USA
2 Department of Ophthalmology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA

Correspondence Address:
Manjot K Gill
Department of Ophthalmology, Northwestern University Feinberg School of Medicine, Chicago, IL
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Source of Support: Supported in part by an unrestricted grant from Research to Prevent Blindness, Inc., New York, NY, Conflict of Interest: None

DOI: 10.4103/2393-8633.158512

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To present a case of choroidal metastases from lung adenocarcinoma treated with intravitreal bevacizumab prior to external beam radiotherapy and systemic chemotherapy. Retrospective interventional. A 72-year-old male, with no significant past ocular or medical history, presented with decreased visual acuity (VA) and a relative scotoma in his left eye. Clinical examination revealed an elevated subretinal lesion in the superotemporal macula in the left eye with fovea-involving subretinal fluid (SRF). Systemic workup revealed metastatic primary adenocarcinoma of the lung. The patient was treated with two intravitreal bevacizumab injections 5 days apart. However, given persistent SRF, external beam radiation and systemic chemotherapy were initiated, which yielded a resolution of SRF, involution of the lesions, and restoration of VA. Although anti-vascular endothelial growth factor (anti-VEGF) therapy represents a therapeutic option for choroidal metastases, enthusiasm for positive results should be tempered. Anti-VEGF agents may be used as adjuncts with other modalities such as external radiotherapy and systemic chemotherapy in the management of such lesions.

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